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KMID : 0352720080320010033
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Journal of Ginseng Research
2008 Volume.32 No. 1 p.33 ~ p.38
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Inhibitory Effect of Fermented Red Ginseng against Passive Cutaneous Anaphylaxis Reaction and Scratching behaviors in Mice
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Bae Eun-Ah
TRINH HIEN-TRUNG
Lee Young-Chul
Kim Sang-Wook
Kim Dong-Hyun
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Abstract
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To evaluate the antiatopic effect of Korea red ginseng (RG, steamed root of Panax ginseng CA Meyer, Family Araliaceae) fermented by Bifidobacterium longum H-1 (FRG), its inhibitory effect on passive cutaneous anaphylaxis (PCA) reaction and itching in mice was measured. FRG and its ingredient saponin fraction (FSF) potently inhibited PCA reaction and scratching behaviors. FRG at a dose of 200 mg/kg and FSF at a dose of 50 mg/kg significantly inhibited the scratching frequency by 45% and 47%, respectively. FRG and FSF also inhibited the degranulation and protein expression of tumor-necrosis and interleukin-4 of RBL-2H3 cells induced by IgE-complex. However, polysaccharide fraction of FRG (FPF) weakly inhibited it, compared with FSF. The inhibitory effect of FRG against PCA reaction and scratching behaviors more potently inhibited than that of RG. Based on these findings, FRG can improve allergic skin disorders atopic dermatitis by the regulation of , and IL-4 produced by mast cells and basophils and its degranulation.
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KEYWORD
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fermented red ginseng, scratching behaviors, passive cutaneous anaphylaxis, atopic dermatitis, allergy
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